After taking Fioricet, wait at least 4 hours before taking anything else that contains caffeine or acetaminophen so you don’t overdose on these ingredients.
This includes Excedrin Migraine, Excedrin Extra Strength, Excedrin Tension Headache, and Excedrin PM Headache.
Butalbital stays in your body for about 35 hours after a single dose of Fioricet.
It causes sleepiness, and taking more doses of Fioricet in this time will make the sleepiness worse.
Avoid alcohol or other relaxant medications while there is still butalbital in your body.