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Acetaminophen in Fioricet

Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues. The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage.

Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. Approximately 85% of an oral dose appears in the urine within 24 hours of administration, most as the glucuronide conjugate, with small amounts of other conjugates and unchanged drug.

Acetaminophen Mechanism of action

Paracetamol (acetaminophen) is generally considered to be a weak inhibitor of the synthesis of prostaglandins (PGs). However, the in vivo effects of paracetamol are similar…

Acetaminophen Manufacturers

There are a lot of manufacturers can produce Acetaminophen. The Main Manufacturers are: Ortho mcneil pharmaceutical inc G and w laboratories inc Able laboratories inc…

Acetaminophen Drug Interactions (5)

Cholic Acid The serum concentration of Acetaminophen can be decreased when it is combined with Cholic Acid. Approved Cholestyramine Cholestyramine can cause a decrease in…

Acetaminophen Drug Interactions (4)

Ezetimibe The serum concentration of Ezetimibe can be increased when it is combined with Acetaminophen. Approved Everolimus The serum concentration of Everolimus can be increased…

Acetaminophen Drug Interactions (3)

Mitotane The serum concentration of Acetaminophen can be decreased when it is combined with Mitotane. Approved Mitomycin The serum concentration of Acetaminophen can be increased…

Acetaminophen Drug Interactions (2)

Reserpine The serum concentration of Acetaminophen can be decreased when it is combined with Reserpine. Approved Regorafenib The serum concentration of Acetaminophen can be increased…

Acetaminophen Drug Interactions

Ziprasidone The metabolism of Acetaminophen can be decreased when combined with Ziprasidone. Approved Zimelidine The serum concentration of Acetaminophen can be increased when it is…

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Posted in Acetaminophen, Fioricet

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