What Is Gabapentin Off Label Usages ?

Neurontin is the trade name for the generic drug gabapentin. It is useful as an anti-epileptic drug and as an analgesic, particularly for pain of the neuropathic or neurogenic type. (pain from irritation or inflammation of nerves). When used for controlling epilepsy, it is usually used in conjunction with another anti-epileptic drug. It is used much more extensively in the medical field to treat pain than it is to treat epilepsy.

Gabapentin belongs to a class of drugs known as anticonvulsants, used to help control seizures in the treatment of epilepsy. Neurontin will only be able to control seizures for as long as you take it. It can’t cure epilepsy. Gabapentin capsules, tablets, and oral solution are used to help control certain types of seizures in people who have epilepsy.

Gabapentin capsules, tablets, and oral solution are also used to relieve the pain of postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last for months or years after an attack of shingles). Gabapentin extended-release tablets (Horizant) are used to treat restless legs syndrome (RLS; a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down). Gabapentin is in a class of medications called anticonvulsants. It has also been reported to be helpful in controlling the pain of fibromyalgia.

Gabapentin treats seizures by decreasing abnormal excitement in the brain. Gabapentin relieves the pain of PHN by changing the way the body senses pain. It is not known exactly how gabapentin works to treat restless legs syndrome.

gabapentin800mgtabGabapentin is also sometimes used to relieve the pain of diabetic neuropathy (numbness or tingling due to nerve damage in people who have diabetes), and to treat and prevent hot flashes (sudden strong feelings of heat and sweating) in women who are being treated for breast cancer or who have experienced menopause (”change of life”, the end of monthly menstrual periods). Talk to your doctor about the risks of using this medication for your condition.

Pregabalin (Lyrica), a drug similar to gabapentin, was the first medication approved by the Food and Drug Administration (FDA) to treat fibromyalgia. While gabapentin hasn’t been approved by the FDA for the treatment of fibromyalgia, some doctors may prescribe it off-label for such use.

Gabapentin and pregabalin were originally approved to treat certain types of epilepsy and nerve pain. Both drugs work by limiting the release of pain-communicating chemicals by nerve cells in the brain and spinal cord. The most common side effects of both drugs are dizziness and drowsiness.

It is also used to control pain associated with shingles and has been evaluated for pain conditions, including migraine, as its pain-modulating properties may regulate the perception of pain.

Anticonvulsant drugs, such as gabapentin, are becoming increasingly popular for migraine prevention.

Efficacy of gabapentin in migraine prophylaxis research on a history of migraine episodes for a mean of about 21 years shows that Gabapentin is an effective prophylactic agent for patients with migraine. In addition, gabapentin appears generally well tolerated with mild to moderate somnolence and dizziness.

Gabapentin is generally well tolerated. The main side effects are dizziness and drowsiness. Occasionally there maybe some fluid retention, unsteadiness or G.I upset, mainly diarrhea.

The effective dose of gabapentin varies greatly. Some persons need only 200-300 mg a day whereas others may need 3000 mg or more a day. It may take several weeks to become effective, so it is important to stay on it for an adequate length of time.

Gabapentin has a lot of off-label usage. It is widely used nerve related diseases. Most of them are reviewed by patients and reviewed high.


General speaking, Gabapentin can be off label used to treat Cough, Hot Flashes, Occipital Neuralgia, Trigeminal Neuralgia, Transverse Myelitis,
Alcohol Withdrawal, Pruritus, Bipolar Disorder, Migraine, Anxiety, Postherpetic Neuralgia, Insomnia, Restless Legs Syndrome, Vulvodynia, Benign Essential Tremor, Peripheral Neuropathy, Fibromyalgia, Diabetic Peripheral Neuropathy, Pain, Neuropathic Pain, Reflex Sympathetic Dystrophy Syndrome, Epilepsy, Hiccups, Syringomyelia, Periodic Limb Movement Disorder, Spondylolisthesis, Burning Mouth Syndrome, Pudendal Neuralgia, Small Fiber Neuropathy, Nausea/Vomiting, Chemotherapy Induced.

Gabapentin Can be used to prevent Migraine

Neurontin® (Gabapentin ) is another Epilepsy medication that is being used as an effective preventive or prophylactic Migraine regiment. As Migraine and Epilepsy are Related diseases, this is actually a sound approach. Neurontin® is an antiepileptic drug, prescribed as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy. Neurontin is also indicated as adjunctive therapy in the treatment of partial seizures in pediatric patients age 3-12 years.. It is typically added to the treatment regimen when other drugs fail to fully control a patient’s attacks.

Gabapentin is quite effective in the treatment of cluster and chronic daily headaches. Most people achieve the reduction of headache frequency within 1-2 weeks.

 

In one study, eight patients with intractable cluster headache were headache-free at a maximum of 8 days after starting gabapentin at the daily dose of 900 mg4. Patients with the episodic type remained headache-free at 3 months after discontinuation of therapy. Patients with chronic cluster were headache-free during the 4 months after initiation of treatment while taking this medication.

The longest period of being continuously headache free on gabapentin was 18 months.

Gabapentin is used for migraine prevention and treatment. It reduces the frequency of headaches, pain intensity, and the use of symptomatic medications. Gabapentin is a good preventive therapy for migraines refractory to other medications.

The double-blind study of 143 patients evaluated gabapentin for migraine prophylaxis. After 3 months the patients taking gabapentin had a reduction of the migraine frequency by 1.5 migraines per month (or by 35.7%) compared with a reduction of 0.6 migraines per month for the placebo group. Also, gabapentin reduced the headache frequency by 50% or greater in 45% patients compared with only 16% patients on placebo.

Gabapentin dosage: 1,200 mg to 2,400 mg per day divided in three doses.

Gabapentin is an effective prophylactic agent for patients with migraine. In addition, gabapentin appears generally well tolerated with mild to moderate somnolence and dizziness.

http://www.ncbi.nlm.nih.gov/pubmed/11251695

Gabapentin For Pain

Gabapentin is off label used for treatment of nerve pain not all kinds of pains. 65% patients think it is effective for pain but as high as 35% think it doesnot work.

bubba smith Reviewed it very good for nerve pain:

“I have severe spine damage. t7 t8 and disc in between basically gone, nerve pain unbelievable. I tried lyrica in large dose and no relief.

Then one doctor said some meds don’t work on some but do on others you just have to get the correct one. So I tried gabapentin and to me it was a life saver, within 3 days the pain was gone or close to gone. 1800 mgs a day ( 6x300mg) plus 40 mg of oxyneo (4x10mg) which is oxycodone time release formula.

The pain specialist say maybe more dose needed but I can’t function properly. That is my minimum dose even drop 1 pill out of them amounts I can feel the difference in pain.

The side effects to me are , tiredness, constipation, memory, blurred vision, moody, seems heat and humid days if outside I get really disoriented so I stay inside”

But a Anonymous guy reviewed it not good for Knee Pain:

“My Husband was given this medication due to suffering long term knee pain. He took it for approx 6 weeks max and had to stop.

The most awful side effects you can imagine for the whole time blighted him.  Maybe he was just unlucky and this med didn’t suit him but it’s Cons certainly outweighed its Pros in his case.

Weight gain Excess gas Dizzyness Nausea Vomiting Diarrhoea Headaches…… Not a good one for him at all. UK Based.”

Because I am a recovering alcoholic it is crucial for me to find non-narcotic treatment for the persevering pain of my chronic pancreatitis.

I was feeling a bit hopeless with the repeated prescriptions of pain meds (which of course offer only temporary relief, and for me a danger of over-use), until my GI prescribed me Gabapentin.

This med has been incredibly successful in mitigating my pain, while also giving me huge energy (I’m a consistent runner so this factor is welcomed), and allowing me to move forward with my sobriety.

I give it four stars, though I realize like anything, it’s not for everyone. That said, good luck to you all with finding what works.

 

Gabapentin For Restless Legs Syndrome

I have suffered with RLS for pretty much my entire life, I’m 55 now. Discovered gabapentin reading blog posts.

I have tried all the other meds. My RLS was getting so bad I was having a lot of episodes during the day and not just at night, but worse at night. I could not sit still to even look at a newspaper or magazine. There were time I actually thought I was going to go completely insane.

Most night I didn’t sleep more than an hour or two. Even then I was not getting a good deep sleep. When I asked my GP about gabapentin, he had no problem prescribing it for me. He even followed recommendation for the dosage.

I take 100mg in the morning and at lunch. Before bedtime I take 200 mg.. All I can say is that this has been a godsend for me.

One of Gabapentin off-label use is to treat Restless Legs Syndrome. 76% patients think Gabapentin is good for RLS. A lot of doctors also recommend its off-label usage for RLS.

Joge siad: “I have had RLS and insomnia since around age nine. I was 1st prescribed gabapentin after herniating a disc three years ago. Didn’t notice any effect on my RLS, but I was so drugged up, I wouldn’t have. I was prescribed it again as a sleep aid two months ago.

I have been taking lorazepam for sleep for years, and wasn’t thrilled about taking 2mg of a benzo every night. It works great for sleep, but I feel hung over the next day — can’t seem to clear the fog. I ran out of gabapentin and noticed, holy cow, my legs are driving me crazy.

Only then did it occur to me – – I hadn’t had any RLS symptoms since I started taking it. I thought I had made a major discovery. LOL. This is the only drug that has ever touched my RLS.”

 

Who can not buy gabapentin Online

You can not buy gabapentin online if you have following health conditions:

1. kidney disease;
2. liver disease;
3. heart disease; or
4. (for patients with RLS) if you are a day sleeper or work a night shift.
5. being pregnant;
6. breast-feeding a baby;
7. Having suicide thoughts.

It does not mean you cannot take gabapentin. If you have above health conditions, you must go to your local street doctor and let the doctor have your health checked.

What you have to know before you take fioricet ?

If you have liver disease, kidney disease, heart disease, or you are drinking alcohol, please donot take fioricet. If you are taking other pain killer than contains acetaminophen, please donot take fioricet; If you have porphyria, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications. Please donot take fioricet.

Do not take Fioricet if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

If you are pregnant, or you are breast feeding, please do not order fioricet online. Go to your street doctors and they may find the best solutions for your headache. If they prescribe you fioricet, you can order online.

Take Fioricet Generic exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

The max dosage is six tablets per day. Never exceed six tablets per day because fioricet contain tylenol (Acetaminophen ), overdose acetaminophen is the most dangerous thing in the world even worse than you addictive to alcohol. Because acetaminophen overdose will seriously damage your kidney and liver. This kind of damage cannot be recovered.

You can take fioricet with water or liquid milk. You can take fioricet with food if you have stomach problems. Never take fioricet with coffee or tea, never take fioricet with some flower drink.

Fioricet is the best pain reliever for tension headache if you take it as soon as the pain begins. If you get warning signs of a migraine, take this medicine as soon as you are sure that the migraine is coming. This may even stop the head pain from occurring. Lying down in a quiet, dark room for a while after taking the medicine also helps to relieve head pain.

What other drugs will affect acetaminophen, butalbital, caffeine, and codeine (Fioricet with Codeine, Phrenilin with Caffeine and Codeine)?

Fioricet Side EffectsDo not take acetaminophen, butalbital, caffeine, and codeine with any other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Tell your doctor about all other medicines you use, especially:

  • glycopyrrolate (Robinul);
  • mepenzolate (Cantil);
  • ciprofloxacin (Cipro);
  • atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
  • bladder or urinary medications such as darifenacin (Enablex), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);
  • a bronchodilator such as ipratropium (Atrovent) or tiotropium (Spiriva);
  • irritable bowel medications such as dicyclomine (Bentyl) or hyoscyamine (Anaspaz, Cystospaz, and others); or
  • an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate).

This list is not complete and other drugs may interact with acetaminophen, butalbital, caffeine, and codeine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Why Fiorinal is Controlled but Fioricet is Not Controlled

Fiorinal and Fioricet are medicines for tension-type headaches. Fiorinal contains aspirin and Fioricet contains acetaminophen. They both contain butalbital and caffeine. Codeine is sometimes also added to this combination. Butalbital, a barbiturate sedative, is habit-forming.

These medications should not be used on a daily basis because dependency on them can develop. Regular use, more than 2 days per week, can cause rebound headache, which may not respond to usually effective acute and preventive treatments.

Some patients are wondering why fioricet is not controlled but fiorinal is controlled. The reasons is that Fiorinal contains aspirin but fioricet only contains non-aspirin pain killer and barbiturate butalbital. The potential for abuse is decreased if a sufficient amount of a non-controlled substance (e.g., aspirin or acetaminophenn) is added.

The ratio required for exemption is 70 mg of acetaminophen to 15 mg of butalbital. In contrast, the ratio of aspirin to butalbital is 188 mg to 15 mg. The acetaminophen to butalbital ratio is approximately 97 mg to 15 mg in Fioricet, thus it is exempt from being controlled. Another reasons is that drug abusers can easily perform an “acid wash” to remove the aspirin (acetylsalicylic acid) component in Fiorinal but It is much more difficult to remove the acetaminophen component in Fioricet. F

What serious side effects may happen if I stop taking Gabapentin and How to treat Gabapentin Withdrawal

Both those who abuse gabapentin and those who take it as prescribed can experience some form of withdrawal when the drug is stopped. Research shows that someone taking gabapentin for as little as 3 weeks, and at doses as low as 400 mg a day, may experience withdrawal.

Gabapentin withdrawal symptoms are similar to those associated with benzodiazepine and alcohol withdrawal and vary from mild to life-threatening. 

The following are withdrawal symptoms one might experience if they stop taking gabapentin abruptly: 

  • Irritability
  • Anxiety
  • Agitation
  • Restlessness
  • Excessive sweating
  • Sensitivity to light
  • Headache
  • Confusion or disorientation
  • Fever
  • Hallucinations
  • Rapid heart rate or heart palpitations
  • Catatonia or inability to move
  • Status epilepticus – a condition where seizures occur one after another (can be fatal)

A physician or medical professionals at a detox facility can safely manage these symptoms.

Several levels of gabapentin withdrawal and abuse treatment are available, and hundreds of facilities throughout the country offer each level of care. The levels of care include:

  • Detox – Gabapentin detox centers specialize in helping people through the acute phase of substance withdrawal. People are supervised around the clock and receive medical and psychiatric attention. Ongoing substance abuse therapy is not the focus at this stage. But the staff will help arrange continued care at another facility following detox. Programs will typically last 3-10 days.
  • Inpatient treatment – Inpatient or residential treatment facilities also provide around-the-clock supervision and care. People meet with psychiatrists, medical doctors, and therapists on a regular basis. Additionally, they may receive individual, group, family, couples, nutritional, and recreational therapy. Inpatient facilities provide a safe place to recover from addiction and focus on mental, behavioral, and lifestyle changes that contribute to long-term recovery. Program lengths typically start at 28 days and can continue for months.
  • Partial hospitalization programs (PHP) and intensive outpatient programs (IOP) – PHPs and IOPs typically take place at psychiatric centers, hospitals, or private practices and primarily focus on group therapy. These programs may also provide weekly family sessions or individual sessions as needed. Many PHPs will include medication management, but IOPs often expect that people have outside providers managing any medications.
  • Individual therapy – Individual therapy can be helpful for learning ways to cope with chronic pain and to help work through issues driving drug abuse.
At this time, no medications have been approved for gabapentin withdrawal treatment. However, physicians may prescribe medications for some of the more uncomfortable side effects of withdrawal.
Your dose of gabapentin may be tapered down over a period of a week to several months to reduce withdrawal symptoms and to avoid complications associated with stopping gabapentin rapidly.

Who Can not Buy Gabapentin On line

Gabapentin is very effective for all kinds of Nerve Pain. But some people are not allowed to Buy Gabapentin online:

1. If you have narcotic medications abuse history, you are not allowed to take tramadol.
2. If you have liver or kidney disease, you are not allowed to order tramadol on line;
3. If you have a stomach disorder, you are not allowed to order tramadol on line;
4. If you are pregnant, you are not allowed to buy tramadol on line;
5. If you have mental illness, you are not allowed to buy tramadol on line;
6. If you have suicide attempt, you are not allowed to buy tramadol on line;
7. If you have alcohol addiction history, you are not allowed to buy tramadol on line;

Gabapentin are not allowed to take at some time, and you are not allowed to take Gabapentin:

1. If you take alcohol in the past few hours;
2. If you take sedatives in the past few hours;
3. If you take stranquilizers in the past few hours;
4. If you take narcotic medications in the past few hours;